I’ve only used 650c wheels, so I can’t compare them to 700c wheels. As for tires/tubes, while some stores do carry 650 tires/tubes, there aren’t as many options as with 700c. I don’t bother with looking for tires at local stores any more. It’s too much of a hassle. The last time I looked, I could only find a couple generic 650c tires, not the Continental GP4000 tires that I was trying to find. Now I just buy them online. (I haven’t had to buy any tubes yet.)
Fortunately, I don’t have to buy tires that often.